abstract：:Experiments were conducted to determine whether oral administration of a water extract of P. dodecandra had significant effects on reproduction in mice. The work is based on earlier reports in this journal that butanol extracts of the berries of this plant had spermatocidal properties in vitro and blastocidal activity...

journal_title：Contraception

authors： Mamo E,Worku M

更新日期：1987-02-01 00:00:00

abstract：:A drug delivery system which provides a sustained release of norethindrone (NET) and mestranol (ME) for one month after a single intramuscular injection was assessed as a long-acting injectable contraceptive. The system is based upon well defined particle size crystals of the synthetic steroids maintained in suspensio...

journal_title：Contraception

authors： Díaz-Sánchez V,Garza-Flores J,Jimenéz-Thomas S,Rudel HW

更新日期：1987-01-01 00:00:00

abstract：:Gossypol has been shown to inhibit steroidogenesis in leydig cells. This study examined the mechanism of this action by investigating the effect of gossypol on leydig cell hCG receptor binding, adenylate cyclase activity and cyclic AMP production in leydig cells. Gossypol had no effect on hCG binding to cell membranes...

journal_title：Contraception

authors： Pearce S,Sufi SB,O'Shaughnessy PJ,Donaldson A,Jeffcoate SL

更新日期：1986-12-01 00:00:00

abstract：:A morphometric study was undertaken to quantitate vessel numbers in uterine biopsies from a control group of patients, patients with dysfunctional uterine bleeding and patients taking low dose norethisterone or levonorgestrel. Vessels were counted at the endometrial/myometrial junction and in the functional endometriu...

journal_title：Contraception

authors： Hourihan HM,Sheppard BL,Bonnar J

更新日期：1986-12-01 00:00:00

abstract：:A two-year controlled clinical study of the effectiveness of postcoital IUD as a continuing contraceptive method in 98 women requesting a postcoital contraception is presented. The control group was selected from women requesting an IUD as contraceptive choice. The rates of accidental pregnancy, expulsion and removal ...

journal_title：Contraception

authors： Gottardi G,Spreafico A,de Orchi L

更新日期：1986-12-01 00:00:00

abstract：:Abortion was attempted in 39 women in early pregnancy (less than 56 days amenorrhea) with the progesterone antagonist RU486 alone (150 mg per day for 4 days) or in combination with a PG analogue, 16,16-dimethyl-trans-delta 2-PGE1 (Gemeprost) in the form of a 1 mg vaginal pessary. Complete abortion was also attempted i...

journal_title：Contraception

authors： Cameron IT,Michie AF,Baird DT

更新日期：1986-11-01 00:00:00

abstract：:A multicentric trial in 9 Spanish Clinics of Family Planning was conducted to evaluate the effectiveness of a vaginal contraceptive Ovule (suppository), containing 18.9 mg of benzalkonium chloride. Gynaecological and cytobacteriological examinations were made to evaluate any possible side-effect. Six-hundred-fifty-thr...

journal_title：Contraception

authors： Méndez F,Castro A,Ortega A

更新日期：1986-10-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamic effects of two doses of norethisterone (5mg and 3mg) used as a 'visiting pill' were investigated. There were no significant differences in the pharmacokinetics of the two doses except for the peak concentration achieved and the bioavailability as assessed by the area under the ...

journal_title：Contraception

authors： Song S,Chen JK,Yang PJ,Cheng DH,Liu WY,Fotherby K

更新日期：1986-09-01 00:00:00

abstract：:Socio-demographic characteristics, general lifestyle habits, reproductive and medical histories were compared of 328 women who had ever used oral contraceptives and 2306 never users from a case-control surveillance conducted in Northern Italy. Oral contraceptive use was positively and strongly related with the level o...

journal_title：Contraception

authors： La Vecchia C,Decarli A,Parazzini F,Gentile A,Negri E,Franceschi S

更新日期：1986-08-01 00:00:00

abstract：:In a cross-over study with orally administered desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) and 3-keto-desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) in ten women under steady-state conditions, the serum levels of 3-keto-desogestrel were monitored by radioimmunoassay. No statistically significant...

journal_title：Contraception

authors： Hasenack HG,Bosch AM,Käär K

更新日期：1986-06-01 00:00:00

abstract：:Open-ended vasectomy was performed on one-hundred men. Sixty-three of them showed up for follow-up six months later. Spontaneous recanalisation had occurred in two. Sperm granuloma without orchialgia was found in 14 out of 59 men (23.9%). Twenty-one out of the 63 thought their sex life had improved, while 40 thought i...

journal_title：Contraception

authors： Temmerman M,Cammu H,Devroey P,Amy JJ

更新日期：1986-06-01 00:00:00

abstract：:To evaluate a potential bias between methods of birth control used and prescribed by physicians, we surveyed sexually active female physicians in regards to their own methods of birth control. When the contraceptive practices of female physicians are compared to those of the general population, no difference in use of...

journal_title：Contraception

authors： Zbella EA,Vermesh M,Gleicher N

更新日期：1986-05-01 00:00:00

abstract：:The aim of this study was to characterize the bleeding pattern, the outcome of pregnancies and the levonorgestrel plasma levels associated with method failures in Norplant implants users. Nineteen pregnancies are reported in 458 woman and 21,589 woman-months observed during the first eight years of Norplant use. Pregn...

journal_title：Contraception

authors： Díaz S,Pavez M,Herreros C,Johansson ED,Croxatto HB

更新日期：1986-04-01 00:00:00

abstract：:Patients taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine together with their oral contraceptive steroid may suffer contraceptive failure because of the enzyme-inducing properties of these anticonvulsants. We have examined, in six women, the effect of sodium valproate, an effective broad spec...

journal_title：Contraception

authors： Crawford P,Chadwick D,Cleland P,Tjia J,Cowie A,Back DJ,Orme ML

更新日期：1986-01-01 00:00:00

abstract：:Benzene extractives of Hibiscus rosa-sinensis flowers, administered during day 1-4 of gestation, exerted anti-implantation effect without affecting the tubal transport of zygote. On day 4, normal number of blastocyst was present in the uterus but they did not implant. However, as studied by pontamine blue reaction, it...

journal_title：Contraception

authors： Pal AK,Bhattacharya K,Kabir SN,Pakrashi A

更新日期：1985-11-01 00:00:00

abstract：:Neo Sampoon is an effervescent contraceptive vaginal tablet manufactured in Japan that contains 60 mg of the spermicide menfegol. Ortho Vaginal Tablets (OVT) and Emko Vaginal Tablets (EVT), both containing 100 mg of the spermicide nonoxynol-9, were manufactured in the USA. The three products were compared in a randomi...

journal_title：Contraception

authors： Lamptey P,Klufio C,Smith SC,Feldblum PJ

更新日期：1985-11-01 00:00:00

abstract：:The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 ...

journal_title：Contraception

authors： Louis SM,Pearson RM

更新日期：1985-08-01 00:00:00

abstract：:Oral contraceptives are in widespread use, and are commonly prescribed for contraception in patients taking other medications. An example of this is the concomitant use of oral contraceptives and anticonvulsants in epileptic patients. This combination creates a potential for drug interactions which may alter the effic...

journal_title：Contraception

authors： Diamond MP,Greene JW,Thompson JM,VanHooydonk JE,Wentz AC

更新日期：1985-06-01 00:00:00

abstract：:This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashio...

journal_title：Contraception

authors： Snyder BW,Schane HP

更新日期：1985-05-01 00:00:00

abstract：:A review of new Zoapatle publications was made, including five chemical compounds characterized recently. Relative potency of Kaurenoic acid, Kauradienoic acid (its mixture), Zoapatanol and Montanol was estimated in an in vitro guinea pig uterine assay. Kaurene compounds were several times more potent than Montanol an...

journal_title：Contraception

authors： Gallegos AJ

更新日期：1985-05-01 00:00:00

abstract：:In a prospective, randomised dose-finding study involving 60 women scheduled for termination of 1st trimester pregnancy, 25 micrograms, 50 micrograms or 100 micrograms of a sulprostone gel with a constant injection volume of 2.5 ml were applied intracervically 6-8 hours before curettage. The gelatinising agent was Plu...

journal_title：Contraception

authors： Rath W,Dennemark N,Gödicke HD

更新日期：1985-03-01 00:00:00

abstract：:Plasma 1-norgestrel (1-Ng) levels after administration of a common oral contraceptive in fertile women (mean age 29 +/- 5 yrs) with mild ulcerative colitis before or after proctocolectomy with a conventional ileostomy or a continent ileostomy reservoir were determined and compared to those of a group of healthy volunt...

journal_title：Contraception

authors： Nilsson LO,Victor A,Kral JG,Johansson ED,Kock NG

更新日期：1985-02-01 00:00:00

abstract：:Sixteen proteinase inhibitors were tested for their ability to compete with the natural seminal inhibitor for binding to the surface of murine epididymal sperm. The most effective competitors, 4-methylumbelliferyl-p-quanidinobenzoate (MUGB) and p-nitrophenyl-p-guanidinobenzoate (NPGB), are also effective inhibitors of...

journal_title：Contraception

authors： Aarons D,Robinson R,Richardson R,Poirier GR

更新日期：1985-02-01 00:00:00

abstract：:Adult female rats were given a single, subcutaneous injection of 8, 16 or 32 micrograms of levonorgestrel (LNG). Blood samples were collected at various time intervals and serum concentrations of LNG were determined by radioimmunoassay. The patterns of temporal decline in LNG concentrations in the three dose groups in...

journal_title：Contraception

authors： Naqvi RH,Mitra SB,Lindberg MC

更新日期：1984-12-01 00:00:00

abstract：:A long-term follow-up study compared development and health of 128 breast-fed children whose mothers had received depot-medroxyprogesterone acetate (depot-MPA) while lactating and 142 control children whose mothers had used mechanical contraceptives or no contraceptives or had undergone sterilization. The children, wh...

journal_title：Contraception

authors： Jimenez J,Ochoa M,Soler MP,Portales P

更新日期：1984-12-01 00:00:00

abstract：:First year results of a randomized study of 1509 users of the Copper T380Ag with a silver core or of an IUD releasing 20 mcg day of levonorgestrel are reported. The cumulative gross pregnancy rate for each device was 0.3 per 100 at one year, with more than 490 women having one year of use with each device. The levonor...

journal_title：Contraception

authors： Sivin I,Alvarez F,Diaz J,Diaz S,el Mahgoub S,Coutinho E,Brache V,Diaz MM,Faundes A,Pavez M

更新日期：1984-11-01 00:00:00

abstract：:The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol. G...

journal_title：Contraception

authors： Kim IC,Waller DP,Marcelle GB,Cordell GA,Fong HH,Pirkle WH,Pilla L,Matlin SA

更新日期：1984-09-01 00:00:00

abstract：:The separate effect of ethinylestradiol (4 micrograms/kg b.w./day) and d-norgestrel (20 micrograms/kg b.w./day) on the fibrinolytic activity in plasma and in vessel walls of the hind leg was investigated in an experimental study on rats. No hormonal effect on the fibrinolytic activity in plasma was registered. However...

journal_title：Contraception

authors： Kjaeldgaard A,Larsson B

更新日期：1984-08-01 00:00:00

abstract：:Fifteen healthy subjects used a contraceptive device, namely an intravaginal ring releasing 20 micrograms levonorgestrel daily, for 12 weeks. High, low and very low density fractions of cholesterol, triglyceride and phospholipids were measured, together with oral glucose tolerance before and after 12 weeks of use. The...

journal_title：Contraception

authors： Elder MG,Lawson JP,Lucas S,Hamawi A,Trayner I,Fotherby K

更新日期：1984-07-01 00:00:00

abstract：:The uterine sound length, the functional length of the cervix including the zone of internal cervical os and the fundus transversal were determined in 795 fertile women in vivo using a measuring device, the Cavimeter. The functional cavity length was calculated by subtracting the functional length of the cervix from t...

journal_title：Contraception

authors： Kurz KH,Tadesse E,Haspels AA

更新日期：1984-06-01 00:00:00

abstract：:RU 486, a new antiprogestational compound, was given to 37 women seeking termination of pregnancy and with amenorrhea of 42 days or less. One patient was found at the second follow-up visit to have an extrauterine pregnancy. The patients received either 25 mg, 50 mg or 100 mg RU 486 twice daily for four days. All pati...

journal_title：Contraception

authors： Kovacs L,Sas M,Resch BA,Ugocsai G,Swahn ML,Bygdeman M,Rowe PJ

更新日期：1984-05-01 00:00:00

abstract：:In pharmacological test models providing repeated daily administrations of steroid hormones, differing time courses of the drug level depending upon the pharmacokinetics can be observed often. The present study should make a contribution to the question whether the time course of the drug level can have an influence o...

journal_title：Contraception

authors： Düsterberg B,Beier S

更新日期：1984-04-01 00:00:00

abstract：:Detailed information was collected from 666 cohorts of pill, injectable-DMPA and IUD acceptors at 14 Bangkok Metropolis Health Clinics (MHCs). The contraceptive status at 12-month follow-up home interview shows that 47% of pill acceptors, 39% of DMPA acceptors and 55% of IUD acceptors were still using the same contrac...

journal_title：Contraception

authors： Chumnijarakij T,Sunyavivat S,Onthuam Y,Udomprasertgul V

更新日期：1984-03-01 00:00:00

abstract：:This review describes the Ford Foundation's program of support of research and training in reproductive science and contraceptive development from 1959 through 1983. An appraisal of some of the merits and limitations of that program and of its impact on the field is also presented. :This report offers a comprehensive...

journal_title：Contraception

authors： Hertz R

更新日期：1984-02-01 00:00:00

abstract：:Twelve young women were prospectively evaluated for the short-term metabolic effects of a low-dose oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms levonorgestrel. To each volunteer a 50 g glucose challenge was administered monthly as a screening test for changes in the glucose metaboli...

journal_title：Contraception

authors： Skouby SO,Wagner HH,Andersen O

更新日期：1983-11-01 00:00:00

abstract：:There is concern that the breast-fed infant whose mother is receiving intra-muscular progestogens for contraception will be exposed to significant quantities of the steroid. Norethisterone levels in maternal serum and milk were studied throughout an injection interval after intramuscular administration of 200mg noreth...

journal_title：Contraception

authors： Fotherby K,Towobola O,Muggeridge J,Elder MG

更新日期：1983-11-01 00:00:00

abstract：:Ovarian function, bleeding patterns and serum lipoproteins were studied in women using contraceptive vaginal rings (CVRs) of dimethyl-polysiloxane impregnated with steroids. The different CVRs were used for about 10 cycles each. The following groups were studied, with the daily steroid dosage given in parentheses. Wom...

journal_title：Contraception

authors： Ahrén T,Victor A,Lithell H,Vessby B,Jackanicz TM,Johansson ED

更新日期：1983-10-01 00:00:00

abstract：:A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...

journal_title：Contraception

authors： Sassolas A,Lagarde M,Guichardant M,Quincy C,Dechavanne M

更新日期：1983-10-01 00:00:00

abstract：:A polyethylene intrauterine device (IUD) inserted in one horn of the rat uterus on Day 2 of pregnancy prevented implantation in 9 out of 12 rats in the horn with the device. When polyphloretin phosphate (PPP), a substance known to inhibit alkaline phosphatase, was administered to such rats from Day 1 till Day 5 of pre...

journal_title：Contraception

authors： Chaudhury MR

更新日期：1983-08-01 00:00:00

abstract：:The Copper T-220C intrauterine device was modified for use in early postpartum insertions. Biodegradable extensions consisting of No. 2 chromic suture were added to the horizontal arms of the device to enhance retention. This new device, Delta-T IUD, was inserted in 100 patients within 55 hours of the delivery of the ...

journal_title：Contraception

authors： Brenner PF

更新日期：1983-08-01 00:00:00